New Hybrids of 4-Amino-2,3-polymethylene-quinoline and <i>p</i>-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer’s Disease Treatment

New Hybrids of 4-Amino-2,3-polymethylene-quinoline and <i>p</i>-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer’s Disease Treatment

New hybrid compounds of 4-amino-2,3-polymethylene-quinoline containing different sizes of the aliphatic ring and linked to <i>p</i>-tolylsulfonamide with alkylene spacers of increasing length were synthesized as potential drugs for treatment of Alzheimer’s disease (AD). All compounds wer...

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Bibliographic Details
Main Authors: Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Elena V. Rudakova, Alexey N. Proshin, Igor V. Serkov, Eugene V. Radchenko, Vladimir A. Palyulin, Sergey O. Bachurin, Rudy J. Richardson
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
4-amino-2,3-polymethylene-quinoline
acetylcholinesterase (AChE)
ADMET
Alzheimer’s disease (AD)
butyrylcholinesterase (BChE)
molecular docking
Online Access:https://www.mdpi.com/1420-3049/25/17/3915

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https://www.mdpi.com/1420-3049/25/17/3915

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