LN Monocytes Limit DC-Poly I:C Induced Cytotoxic T Cell Response via IL-10 and Induction of Suppressor CD4 T Cells

LN Monocytes Limit DC-Poly I:C Induced Cytotoxic T Cell Response via IL-10 and Induction of Suppressor CD4 T Cells

Every immune response has accelerators and brakes. Depending on the pathogen or injury, monocytes can play either role, promoting or resolving immunity. Poly I:C, a potent TLR3 ligand, licenses cross-presenting dendritic cells (DC1) to accelerate a robust cytotoxic T cells response against a foreign...

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Bibliographic Details
Main Authors: Anita Tewari, Miglena G. Prabagar, Sophie L. Gibbings, Kavita Rawat, Claudia V. Jakubzick
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
Ly6C+ monocytes
antigen-presentation
IL-10
cytotoxic T cells
Poly I:C
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.763379/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.763379/full

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