Multiple Sclerosis: LIFNano-CD4 for Trojan Horse Delivery of the Neuro-Protective Biologic “LIF” Into the Brain: Preclinical Proof of Concept

Multiple Sclerosis: LIFNano-CD4 for Trojan Horse Delivery of the Neuro-Protective Biologic “LIF” Into the Brain: Preclinical Proof of Concept

Multiple sclerosis (MS) is a demyelinating autoimmune disease that attacks the brain, with year-on-year loss of brain volume, starting late teens and becoming manifest late twenties. There is no cure, and current therapies are immunosuppressive only. LIF is a vital stem cell growth factor active thr...

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Bibliographic Details
Main Authors: Raul de la Flor, Janette Robertson, Rostislav V. Shevchenko, Mo Alavijeh, Sean Bickerton, Tarek Fahmy, Su M. Metcalfe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Medical Technology
Subjects:
LIF
BBB
CD4+ T lymphocyte
PLGA nanoparticles
pK/pD
EAE
Online Access:https://www.frontiersin.org/articles/10.3389/fmedt.2021.640569/full

Internet

https://www.frontiersin.org/articles/10.3389/fmedt.2021.640569/full

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