Identification of a novel peptide ligand for the cancer-specific receptor mutation EGFRvIII using high-throughput sequencing of phage-selected peptides

Identification of a novel peptide ligand for the cancer-specific receptor mutation EGFRvIII using high-throughput sequencing of phage-selected peptides

Abstract We report here the selection and characterization of a novel peptide ligand using phage display targeted against the cancer-specific epidermal growth factor tyrosine kinase receptor mutation variant III (EGFRvIII). This receptor is expressed in several kinds of cancer: ovarian cancer, breas...

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Main Authors: Sourour Mansour, Indranil Adhya, Coralie Lebleu, Rama Dumpati, Ahmed Rehan, Santu Chall, Jingqi Dai, Gauthier Errasti, Thomas Delacroix, Raj Chakrabarti
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25257-4

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https://doi.org/10.1038/s41598-022-25257-4

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