The M. tuberculosis Rv1523 Methyltransferase Promotes Drug Resistance Through Methylation-Mediated Cell Wall Remodeling and Modulates Macrophages Immune Responses

The M. tuberculosis Rv1523 Methyltransferase Promotes Drug Resistance Through Methylation-Mediated Cell Wall Remodeling and Modulates Macrophages Immune Responses

The acquisition of antibiotics resistance is a major clinical challenge limiting the effective prevention and treatment of the deadliest human infectious disease tuberculosis. The molecular mechanisms by which initially Mycobacterium tuberculosis (M.tb) develop drug resistance remain poorly understo...

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Bibliographic Details
Main Authors: Sabeeha Ali, Aquib Ehtram, Naresh Arora, P. Manjunath, Deodutta Roy, Nasreen Z. Ehtesham, Seyed E. Hasnain
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
MTases
antibiotics resistance
methyltransferases
cell envelope lipids
immune responses
Mycobacterium smegmatis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.622487/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.622487/full

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