The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer

The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer

p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically involved in several important cellular processes. Via its pronounced domain architecture, p62 binds to numerous interaction partners, thereby influencing key pathways that regulate tissue homeostasis, inflammati...

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Bibliographic Details
Main Authors: Paulina Hennig, Gabriele Fenini, Michela Di Filippo, Tugay Karakaya, Hans-Dietmar Beer
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
p62
autophagy
inflammasomes
Nrf2/Keap1
NF-κB
mTORC1
Online Access:https://www.mdpi.com/2227-9059/9/7/707

Internet

https://www.mdpi.com/2227-9059/9/7/707

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