Transcriptional signature in microglia associated with Aβ plaque phagocytosis

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

Microglia associated with Aβ plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer’s disease (AD) models. Here the authors show that amyloid plaque phagocytosis is associated with a specific microglia transcriptional signature in a mou...

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Bibliographic Details
Main Authors: Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Guizhi Sun, Nathan P. Croft, Fernando J. Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H. Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M. Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, Colin W. Pouton, Anthony W. Purcell, Owen J. L. Rackham, Enrico Petretto, Jose M. Polo
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23111-1

Internet

https://doi.org/10.1038/s41467-021-23111-1

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