Functional characterization of missense variants affecting the extracellular domains of ABCA1 using a fluorescence-based assay

Functional characterization of missense variants affecting the extracellular domains of ABCA1 using a fluorescence-based assay

Excess cholesterol originating from nonhepatic tissues is transported within HDL particles to the liver for metabolism and excretion. Cholesterol efflux is initiated by lipid-free or lipid-poor apolipoprotein A1 interacting with the transmembrane protein ABCA1, a key player in cholesterol homeostasi...

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Bibliographic Details
Main Authors: Marianne Teigen, Åsa Schawlann Ølnes, Katrine Bjune, Trond P. Leren, Martin Prøven Bogsrud, Thea Bismo Strøm
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Lipid Research
Subjects:
HEK293 cells
Tangier disease
cholesterol efflux
BODIPY-cholesterol
HDL
ApoA1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523001554

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http://www.sciencedirect.com/science/article/pii/S0022227523001554

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