In Vitro and In Vivo Studies for the Investigation of γ-Globin Gene Induction by Adhatoda vasica: A Pre-Clinical Study of HbF Inducers for β-Thalassemia

In Vitro and In Vivo Studies for the Investigation of γ-Globin Gene Induction by Adhatoda vasica: A Pre-Clinical Study of HbF Inducers for β-Thalassemia

Fetal hemoglobin (HbF) is a potent genetic modifier, and the γ-globin gene induction has proven to be a sustainable therapeutic approach for the management of β-thalassemia. In this study, we have evaluated the HbF induction ability of A. vasica in vitro and in vivo, and the identification of potent...

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Bibliographic Details
Main Authors: Fizza Iftikhar, Saeedur Rahman, Muhammad Behroz Naeem Khan, Kanwal Khan, Muhammad Noman Khan, Reaz Uddin, Syed Ghulam Musharraf
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
erythroid differentiation
bioassay-guided isolation
Adhatoda vasica
pyrroquinazoline alkaloids
hematological indices
HbF induction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.797853/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.797853/full

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