Clinical outcome of type 2 diabetic patients after kidney transplantation: Systematic review

Aim: To conduct a systematic review to summarize the outcome of adult patients with history of type II DM after renal transplantation [RTx] in following category of patients: (1) type 2 DM; (2) type 2 DM vs Non-DM; (3) type 2 DM vs Dialysis; (4) Preemptive Kidney Transplant (prekTx) vs non prekTx. M...

Full description

Bibliographic Details
Main Authors: Veena Joshi, Sishir Gang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Indian Journal of Transplantation
Subjects:
Online Access:http://www.ijtonline.in/article.asp?issn=2212-0017;year=2017;volume=11;issue=1;spage=1;epage=6;aulast=Joshi;type=0
_version_ 1818541382121291776
author Veena Joshi
Sishir Gang
author_facet Veena Joshi
Sishir Gang
author_sort Veena Joshi
collection DOAJ
description Aim: To conduct a systematic review to summarize the outcome of adult patients with history of type II DM after renal transplantation [RTx] in following category of patients: (1) type 2 DM; (2) type 2 DM vs Non-DM; (3) type 2 DM vs Dialysis; (4) Preemptive Kidney Transplant (prekTx) vs non prekTx. Method: MEDLINE, EMBASE, Renal transplant registries were searched for observational/cohort/casecontrol studies from 1980 to 2015. Results: We identified 10 studies reporting outcome of kidney transplantation in patients with type 2 DM[type 2 DM(2), type2 DM vs Non-DM (6), type 2 DMvs Dialysis (1), prekTx vs non-prekTx (1)]. One and five year graft survival ranged from 76% to 100% and 53% to 96% respectively. 8, 4, 8, and 2 studies showed 1, 3, 5 and 10 yr patient survival respectively. Recent study with type 2 DM patients showed at 10 yrs, graft survival did not differ between Non-DM and type 2 DM but Non-DM patient survival was better (p < .001) than type 2 DM patients after RTx. At 5 yrs, patient survival ranged from 29% to 97%. Graft and patient survival did not differ between type 2 DM and Non-DM patients in three and two studies respectively. A study showed at 10 yrs, survival after RTx was significantly (p < .001) better than patients on dialysis. Preemptive transplant study reported lower adjusted graft failure and mortality risk for type 2 DM transplant recipients from living donors compared to deceased donors. Conclusion: Results from these few single center studies demonstrate the need for multicenter rigorous studies to look at long term survival of type 2 diabetes patients after renal transplant.
first_indexed 2024-12-11T22:08:33Z
format Article
id doaj.art-9f5af08e3d0a4805a28fe49104f2f31b
institution Directory Open Access Journal
issn 2212-0017
2212-0025
language English
last_indexed 2024-12-11T22:08:33Z
publishDate 2017-01-01
publisher Wolters Kluwer Medknow Publications
record_format Article
series Indian Journal of Transplantation
spelling doaj.art-9f5af08e3d0a4805a28fe49104f2f31b2022-12-22T00:48:53ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252017-01-011111610.1016/j.ijt.2016.09.093Clinical outcome of type 2 diabetic patients after kidney transplantation: Systematic reviewVeena JoshiSishir GangAim: To conduct a systematic review to summarize the outcome of adult patients with history of type II DM after renal transplantation [RTx] in following category of patients: (1) type 2 DM; (2) type 2 DM vs Non-DM; (3) type 2 DM vs Dialysis; (4) Preemptive Kidney Transplant (prekTx) vs non prekTx. Method: MEDLINE, EMBASE, Renal transplant registries were searched for observational/cohort/casecontrol studies from 1980 to 2015. Results: We identified 10 studies reporting outcome of kidney transplantation in patients with type 2 DM[type 2 DM(2), type2 DM vs Non-DM (6), type 2 DMvs Dialysis (1), prekTx vs non-prekTx (1)]. One and five year graft survival ranged from 76% to 100% and 53% to 96% respectively. 8, 4, 8, and 2 studies showed 1, 3, 5 and 10 yr patient survival respectively. Recent study with type 2 DM patients showed at 10 yrs, graft survival did not differ between Non-DM and type 2 DM but Non-DM patient survival was better (p < .001) than type 2 DM patients after RTx. At 5 yrs, patient survival ranged from 29% to 97%. Graft and patient survival did not differ between type 2 DM and Non-DM patients in three and two studies respectively. A study showed at 10 yrs, survival after RTx was significantly (p < .001) better than patients on dialysis. Preemptive transplant study reported lower adjusted graft failure and mortality risk for type 2 DM transplant recipients from living donors compared to deceased donors. Conclusion: Results from these few single center studies demonstrate the need for multicenter rigorous studies to look at long term survival of type 2 diabetes patients after renal transplant.http://www.ijtonline.in/article.asp?issn=2212-0017;year=2017;volume=11;issue=1;spage=1;epage=6;aulast=Joshi;type=0Diabetes mellitusDialysisGraft survivalTransplantRenal insufficiency
spellingShingle Veena Joshi
Sishir Gang
Clinical outcome of type 2 diabetic patients after kidney transplantation: Systematic review
Indian Journal of Transplantation
Diabetes mellitus
Dialysis
Graft survival
Transplant
Renal insufficiency
title Clinical outcome of type 2 diabetic patients after kidney transplantation: Systematic review
title_full Clinical outcome of type 2 diabetic patients after kidney transplantation: Systematic review
title_fullStr Clinical outcome of type 2 diabetic patients after kidney transplantation: Systematic review
title_full_unstemmed Clinical outcome of type 2 diabetic patients after kidney transplantation: Systematic review
title_short Clinical outcome of type 2 diabetic patients after kidney transplantation: Systematic review
title_sort clinical outcome of type 2 diabetic patients after kidney transplantation systematic review
topic Diabetes mellitus
Dialysis
Graft survival
Transplant
Renal insufficiency
url http://www.ijtonline.in/article.asp?issn=2212-0017;year=2017;volume=11;issue=1;spage=1;epage=6;aulast=Joshi;type=0
work_keys_str_mv AT veenajoshi clinicaloutcomeoftype2diabeticpatientsafterkidneytransplantationsystematicreview
AT sishirgang clinicaloutcomeoftype2diabeticpatientsafterkidneytransplantationsystematicreview