Clinical protocol: Feasibility of evaluating abemaciclib neuropharmacokinetics of diffuse midline glioma using intratumoral microdialysis.

Clinical protocol: Feasibility of evaluating abemaciclib neuropharmacokinetics of diffuse midline glioma using intratumoral microdialysis.

Diffuse midline gliomas (DMG) are the most aggressive brain tumors of childhood and young adults, with documented 2-year survival rates <10%. Treatment failure is due in part to the function of the BBB. Intratumoral microdialysis sampling is an effective tool to determine brain entry of varied ag...

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Bibliographic Details
Main Authors: Edjah K Nduom, John Glod, Desmond A Brown, Margaret Fagan, Mahalia Dalmage, John Heiss, Seth M Steinberg, Cody Peer, William D Figg, Sadhana Jackson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0291068

Internet

https://doi.org/10.1371/journal.pone.0291068

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