Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages

Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages

Abstract Viral fusion proteins facilitate cellular infection by fusing viral and cellular membranes, which involves dramatic transitions from their pre- to postfusion conformations. These proteins are among the most protective viral immunogens, but they are metastable which often makes them intracta...

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Bibliographic Details
Main Authors: Sonal V. Gidwani, Devarshi Brahmbhatt, Aaron Zomback, Mamie Bassie, Jennifer Martinez, Jian Zhuang, John Schulze, Jason S. McLellan, Roberto Mariani, Peter Alff, Daniela Frasca, Bonnie B. Blomberg, Christopher P. Marshall, Mark A. Yondola
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46295-8

Internet

https://doi.org/10.1038/s41467-024-46295-8

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