Reclassification of variants of uncertain significance by race, ethnicity, and ancestry for patients at risk for breast cancer

IntroductionAlthough most variants of uncertain significance (VUS) in breast cancer susceptibility genes are eventually downgraded to benign or likely benign in individuals of European ancestry, it is unclear if this also applies to non-European populations. This study examines the time to and type...

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Bibliographic Details
Main Authors: Versha Pleasant, Jordyn Boggan, Blair Richards, Kara J. Milliron, Kristen S. Purrington, Michael Simon, Sofia Merajver
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1455509/full