Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease

Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease

The accumulation of proteinaceous deposits comprised largely of the α-synuclein protein is one of the main hallmarks of Parkinson's disease (PD) and related synucleinopathies. Their progressive development coincides with site-specific phosphorylation, oxidative stress and eventually, compromise...

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Bibliographic Details
Main Authors: Serge Moudio, Fredrik Rodin, Nazira Jamal Albargothy, Urban Karlsson, Juan F. Reyes, Martin Hallbeck
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Neurology
Subjects:
Parkinson's disease
α-synuclein
PFF
organotypic slice cultures
autophagy
3R
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.826102/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2022.826102/full

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