From Far West to East: Joining the Molecular Architecture of Imidazole-like Ligands in HO-1 Complexes

HO-1 overexpression has been reported in several cases/types of human malignancies. Unfortunately, poor clinical outcomes are reported in most of these cases, and the inhibition of HO-1 is considered a valuable and proven anticancer approach. To identify novel hit compounds suitable as HO-1 inhibito...

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Bibliographic Details
Main Authors: Giuseppe Floresta, Antonino Nicolò Fallica, Vincenzo Patamia, Valeria Sorrenti, Khaled Greish, Antonio Rescifina, Valeria Pittalà
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
Online Access:https://www.mdpi.com/1424-8247/14/12/1289