Dilated cardiomyopathy mutation (R134W) in mouse cardiac troponin T induces greater contractile deficits against α-myosin heavy chain than against β-myosin heavy chain

Dilated cardiomyopathy mutation (R134W) in mouse cardiac troponin T induces greater contractile deficits against α-myosin heavy chain than against β-myosin heavy chain

Many studies have demonstrated that depressed myofilament Ca2+ sensitivity is common to dilated cardiomyopathy (DCM) in humans. However, it remains unclear whether a single determinant — such as myofilament Ca2+ sensitivity — is sufficient to characterize all cases of DCM because the severity of di...

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Bibliographic Details
Main Authors: Sampath K Gollapudi, Murali Chandra
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Physiology
Subjects:
Troponin T
myosin heavy chain
dilated cardiomyopathy
contractile dynamics
thin filament function
myofilament cooperativity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00443/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00443/full

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