Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity

Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity

A series of isoniazid derivatives bearing a phenolic or heteroaromatic coupled frame were obtained by mechanochemical means. Their pH stability and their structural (conformer/isomer) analysis were checked. The activity of prepared derivatives against Mycobacterium tuberculosis cell growth was evalu...

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Bibliographic Details
Main Authors: Paulo F. M. Oliveira, Brigitte Guidetti, Alain Chamayou, Christiane André-Barrès, Jan Madacki, Jana Korduláková, Giorgia Mori, Beatrice Silvia Orena, Laurent Roberto Chiarelli, Maria Rosalia Pasca, Christian Lherbet, Chantal Carayon, Stéphane Massou, Michel Baron, Michel Baltas
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
Mycobacterium tuberculosis
mechanochemistry
hydrazone
Online Access:https://www.mdpi.com/1420-3049/22/9/1457

Internet

https://www.mdpi.com/1420-3049/22/9/1457

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