Blockade of Mbd2 by siRNA-loaded liposomes protects mice against OVA-induced allergic airway inflammation via repressing M2 macrophage production

Blockade of Mbd2 by siRNA-loaded liposomes protects mice against OVA-induced allergic airway inflammation via repressing M2 macrophage production

ObjectiveTo address the role of methyl-CpG-binding domain 2 (MBD2) in the pathogenesis of asthma and its potential as a target for the asthmatic therapy.MethodsStudies were conducted in asthmatic patients and macrophage-specific Mbd2 knockout mice to dissect the role of MBD2 in asthma pathogenesis....

Full description

Bibliographic Details
Main Authors: Guo-Rao Wu, Min Zhou, Yi Wang, Qing Zhou, Lei Zhang, Long He, Shu Zhang, Qilin Yu, Yongjian Xu, Jianping Zhao, Weining Xiong, Cong-Yi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
asthma
macrophage
alternatively activated macrophages
MBD2
liposomes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.930103/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.930103/full

Similar Items