Engineering a suite of E. coli strains for enhanced expression of bacterial polysaccharides and glycoconjugate vaccines

Engineering a suite of E. coli strains for enhanced expression of bacterial polysaccharides and glycoconjugate vaccines

Abstract Background Glycoengineering, in the biotechnology workhorse bacterium, Escherichia coli, is a rapidly evolving field, particularly for the production of glycoconjugate vaccine candidates (bioconjugation). Efficient production of glycoconjugates requires the coordinated expression within the...

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Bibliographic Details
Main Authors: Emily J. Kay, Marta Mauri, Sam J. Willcocks, Timothy A. Scott, Jon Cuccui, Brendan W. Wren
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Microbial Cell Factories
Subjects:
Biological conjugation
Streptococcus pneumoniae
Glycoengineering
Vaccine
PglB
Glycoconjugates
Online Access:https://doi.org/10.1186/s12934-022-01792-7

Internet

https://doi.org/10.1186/s12934-022-01792-7

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