Serum levels of neurofilament light-chain (NfL), a biomarker of axonal and synaptic damage, predict 5-year outcome in acutely ill schizophrenia patients

Serum levels of neurofilament light-chain (NfL), a biomarker of axonal and synaptic damage, predict 5-year outcome in acutely ill schizophrenia patients

Background: Disruptions of neuronal macro- and microcircuits in schizophrenia (SCZ) have been attributed to pathologies of neuronal connectivity. We hypothesized that during acute psychosis structural damage to axons and synapses occurs in a subset of patients, rendering them more susceptible to poo...

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Bibliographic Details
Main Authors: David Popovic, Kolja Schiltz, Henrik Dobrowolny, Gabriela Meyer-Lotz, Paul C. Guest, Wolfgang Jordan, Katrin Borucki, Nikolaos Koutsouleris, Bernhard Bogerts, Hans-Gert Bernstein, Alessandra Mandelli, Sabine Bahn, Roberto Furlan, Johann Steiner
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Journal of Affective Disorders Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2666915323001075

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http://www.sciencedirect.com/science/article/pii/S2666915323001075

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