Inhibition of endothelial Nox2 activation by LMH001 protects mice from angiotensin II-induced vascular oxidative stress, hypertension and aortic aneurysm

Inhibition of endothelial Nox2 activation by LMH001 protects mice from angiotensin II-induced vascular oxidative stress, hypertension and aortic aneurysm

Endothelial oxidative stress and inflammation attributable to the activation of a Nox2-NADPH oxidase are key features of many cardiovascular diseases. Here, we report a novel small chemical compound (LMH001, MW = 290.079), by blocking phosphorylated p47phox interaction with p22phox, inhibited effect...

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Bibliographic Details
Main Authors: Lampson M. Fan, Fangfei Liu, Junjie Du, Li Geng, Jian-Mei Li
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Redox Biology
Subjects:
Nox2 inhibitor
Angiotensin II
Vascular oxidative stress
Hypertension
Aortic aneurysm
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000416

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http://www.sciencedirect.com/science/article/pii/S2213231722000416

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