Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications.

The understanding of G-protein coupled receptors (GPCRs) is undergoing a revolution due to increased information about their signaling and the experimental determination of structures for more than 25 receptors. The availability of at least one receptor structure for each of the GPCR classes, well s...

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Bibliographic Details
Main Authors: Vaclav Cvicek, William A Goddard, Ravinder Abrol
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4814114?pdf=render