GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

Background: Mitochondrial DNA copy number (mtDNA-CN) is an accessible blood-based measurement believed to capture underlying mitochondrial (MT) function. The specific biological processes underpinning its regulation, and whether those processes are causative for disease, is an area of active investi...

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Bibliographic Details
Main Authors: Michael Chong, Pedrum Mohammadi-Shemirani, Nicolas Perrot, Walter Nelson, Robert Morton, Sukrit Narula, Ricky Lali, Irfan Khan, Mohammad Khan, Conor Judge, Tafadzwa Machipisa, Nathan Cawte, Martin O'Donnell, Marie Pigeyre, Loubna Akhabir, Guillaume Paré
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
mitochondrial DNA copy number
genome-wide association study
Mendelian randomization
dementia
Online Access:https://elifesciences.org/articles/70382

Internet

https://elifesciences.org/articles/70382

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