A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC–OXPHOS axis

A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC–OXPHOS axis

Abstract Background Ovarian cancer (OC) is the most lethal malignant gynecological tumor type for which limited therapeutic targets and drugs are available. Enhanced mitochondrial oxidative phosphorylation (OXPHOS), which enables cell growth, migration, and cancer stem cell maintenance, is a critica...

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Bibliographic Details
Main Authors: Ruibin Jiang, Zhongjian Chen, Maowei Ni, Xia Li, Hangjie Ying, Jianguo Fen, Danying Wan, Chanjuan Peng, Wei Zhou, Linhui Gu
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Translational Medicine
Subjects:
Ovarian cancer
Oxidative phosphorylation
Gossypol acetic acid
LRPPRC
Online Access:https://doi.org/10.1186/s12967-023-04349-3

Internet

https://doi.org/10.1186/s12967-023-04349-3

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