Knockdown of the bovine prion gene PRNP by RNA interference (RNAi) technology

<p>Abstract</p> <p>Background</p> <p>Since prion gene-knockout mice do not contract prion diseases and animals in which production of prion protein (PrP) is reduced by half are resistant to the disease, we hypothesized that bovine animals with reduced PrP would be toler...

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Bibliographic Details
Main Authors: Wongsrikeao Pimprapar, Kudo Toshiyuki, Kunishi Miho, Sutou Shizuyo, Miyagishi Makoto, Otoi Takeshige
Format: Article
Language:English
Published: BMC 2007-07-01
Series:BMC Biotechnology
Online Access:http://www.biomedcentral.com/1472-6750/7/44