PPARβ/δ accelerates bone regeneration in diabetic mellitus by enhancing AMPK/mTOR pathway-mediated autophagy

PPARβ/δ accelerates bone regeneration in diabetic mellitus by enhancing AMPK/mTOR pathway-mediated autophagy

Abstract Background Diabetic patients are more vulnerable to skeletal complications. Peroxisome proliferators-activated receptor (PPAR) β/δ has a positive regulatory effect on bone turnover under physiologic glucose concentration; however, the regulatory effect in diabetes mellitus has not been inve...

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Bibliographic Details
Main Authors: Miao Chen, Dian Jing, Rui Ye, Jianru Yi, Zhihe Zhao
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Stem Cell Research & Therapy
Subjects:
PPARβ/δ
Diabetes mellitus
Autophagy
Osteogenic differentiation
Bone regeneration
AMPK/mTOR pathway
Online Access:https://doi.org/10.1186/s13287-021-02628-8

Internet

https://doi.org/10.1186/s13287-021-02628-8

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