The role of endothelin-1 in the doxorubicin cardiotoxicity
Background: The cardiotoxicity of doxorubicin (Dx), an antineoplastic drug, is imposed by the development of cardiomyopathy and heart failure. The expression of endothelin-1 (ET-1) in myocardium under the action of Dx, directly correlates with the degree of cardiac dysfunction, mediated by endothe...
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| Format: | Article |
| Language: | English |
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Scientific Medical Association of Moldova
2020-10-01
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| Series: | The Moldovan Medical Journal |
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| Online Access: | http://moldmedjournal.md/wp-content/uploads/2020/09/moldovan-med-j-2020-63-4-tacu-full-text.pdf |
| _version_ | 1819205587867533312 |
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| author | Lilia Tacu |
| author_facet | Lilia Tacu |
| author_sort | Lilia Tacu |
| collection | DOAJ |
| description | Background: The cardiotoxicity of doxorubicin (Dx), an antineoplastic drug, is imposed by the development of cardiomyopathy and heart failure.
The expression of endothelin-1 (ET-1) in myocardium under the action of Dx, directly correlates with the degree of cardiac dysfunction, mediated by
endothelin A (ETA) receptor.
Material and methods: For prospective randomized study 2 groups of white rats (experimental group n=9, control group n=9) were used. During 2
weeks in the control group was administrated Dx (i/p, 4mg/kg in one dose, twice/week), cumulative dose – 16 mg/kg. The ET-1 effects were estimated
at its peak action in concentration 10-7 M (mol), reproduced after 30 sec of endothelin stimulation.
Results: The functional parameters of isolated heart perfused in physiologic regime and in condition of volume and resistance overload under the ET-1
action in the group with Dx compared with the control one, were reduced considerably, namely: cardiac output (CO); left ventricle systolic pressure
(LVSP); left ventricle end-diastolic pressure (LVEDP).
Conclusions: Under the ET-1 action on the isolated heart perfused in physiologic regime in the group with Dx – the LVSP and CO were reduced determining
negative inotropic effect. At the volume overload test, under the ET-1 action, the diastolic impairment was more evident in the group with Dx, due to
increased LVEDP. At the resistance overload test under the ET-1 action, the CO was reduced indicating the depreciation of myocardial contraction capacity. |
| first_indexed | 2024-12-23T04:54:05Z |
| format | Article |
| id | doaj.art-9f805bfb9c0f42ffaab165ac84c92ba7 |
| institution | Directory Open Access Journal |
| issn | 2537-6373 2537-6381 |
| language | English |
| last_indexed | 2024-12-23T04:54:05Z |
| publishDate | 2020-10-01 |
| publisher | Scientific Medical Association of Moldova |
| record_format | Article |
| series | The Moldovan Medical Journal |
| spelling | doaj.art-9f805bfb9c0f42ffaab165ac84c92ba72022-12-21T17:59:23ZengScientific Medical Association of MoldovaThe Moldovan Medical Journal2537-63732537-63812020-10-01634434810.5281/zenodo.4016812The role of endothelin-1 in the doxorubicin cardiotoxicityLilia Tacu0https://orcid.org/0000-0003-0940-2527Department of Pathophysiology and Clinical Pathophysiology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: The cardiotoxicity of doxorubicin (Dx), an antineoplastic drug, is imposed by the development of cardiomyopathy and heart failure. The expression of endothelin-1 (ET-1) in myocardium under the action of Dx, directly correlates with the degree of cardiac dysfunction, mediated by endothelin A (ETA) receptor. Material and methods: For prospective randomized study 2 groups of white rats (experimental group n=9, control group n=9) were used. During 2 weeks in the control group was administrated Dx (i/p, 4mg/kg in one dose, twice/week), cumulative dose – 16 mg/kg. The ET-1 effects were estimated at its peak action in concentration 10-7 M (mol), reproduced after 30 sec of endothelin stimulation. Results: The functional parameters of isolated heart perfused in physiologic regime and in condition of volume and resistance overload under the ET-1 action in the group with Dx compared with the control one, were reduced considerably, namely: cardiac output (CO); left ventricle systolic pressure (LVSP); left ventricle end-diastolic pressure (LVEDP). Conclusions: Under the ET-1 action on the isolated heart perfused in physiologic regime in the group with Dx – the LVSP and CO were reduced determining negative inotropic effect. At the volume overload test, under the ET-1 action, the diastolic impairment was more evident in the group with Dx, due to increased LVEDP. At the resistance overload test under the ET-1 action, the CO was reduced indicating the depreciation of myocardial contraction capacity.http://moldmedjournal.md/wp-content/uploads/2020/09/moldovan-med-j-2020-63-4-tacu-full-text.pdfdoxorubicin cardiomyopathyendothelin-1coronary flowheart reactivity |
| spellingShingle | Lilia Tacu The role of endothelin-1 in the doxorubicin cardiotoxicity The Moldovan Medical Journal doxorubicin cardiomyopathy endothelin-1 coronary flow heart reactivity |
| title | The role of endothelin-1 in the doxorubicin cardiotoxicity |
| title_full | The role of endothelin-1 in the doxorubicin cardiotoxicity |
| title_fullStr | The role of endothelin-1 in the doxorubicin cardiotoxicity |
| title_full_unstemmed | The role of endothelin-1 in the doxorubicin cardiotoxicity |
| title_short | The role of endothelin-1 in the doxorubicin cardiotoxicity |
| title_sort | role of endothelin 1 in the doxorubicin cardiotoxicity |
| topic | doxorubicin cardiomyopathy endothelin-1 coronary flow heart reactivity |
| url | http://moldmedjournal.md/wp-content/uploads/2020/09/moldovan-med-j-2020-63-4-tacu-full-text.pdf |
| work_keys_str_mv | AT liliatacu theroleofendothelin1inthedoxorubicincardiotoxicity AT liliatacu roleofendothelin1inthedoxorubicincardiotoxicity |