Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease

Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease

Abstract Castleman disease (CD) is a rare lymphoproliferative disorder. Among subtypes of CD, idiopathic multicentric CD-not otherwise specified (iMCD-NOS) has a poor prognosis and its pathogenesis is largely unknown. Here we present a xenotransplantation model of iMCD-NOS pathogenesis. Immunodefici...

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Bibliographic Details
Main Authors: Takuya Harada, Yoshikane Kikushige, Toshihiro Miyamoto, Kazuko Uno, Hiroaki Niiro, Atsushi Kawakami, Tomohiro Koga, Koichi Akashi, Kazuyuki Yoshizaki
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42718-0

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https://doi.org/10.1038/s41467-023-42718-0

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