MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway.

MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway.

IL-2 plays a key role in the survival and proliferation of immune cells, especially T lymphocytes. Its expression is precisely regulated at transcriptional and posttranscriptional level. IL-2 is known to be regulated by RNA binding proteins, such as tristetraprolin (TTP), via an AU-rich element (ARE...

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Bibliographic Details
Main Authors: Min Li, Wenqiang Cao, Haifeng Liu, Wei Zhang, Xia Liu, Zhijian Cai, Jing Guo, Xuelian Wang, Zhaoyuan Hui, Hang Zhang, Jianli Wang, Lie Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3504106?pdf=render

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http://europepmc.org/articles/PMC3504106?pdf=render

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