Targeting Pin1 by All-Trans Retinoic Acid (ATRA) Overcomes Tamoxifen Resistance in Breast Cancer via Multifactorial Mechanisms

Targeting Pin1 by All-Trans Retinoic Acid (ATRA) Overcomes Tamoxifen Resistance in Breast Cancer via Multifactorial Mechanisms

Breast cancer is the most prevalent tumor in women worldwide and about 70% patients are estrogen receptor positive. In these cancer patients, resistance to the anticancer estrogen receptor antagonist tamoxifen emerges to be a major clinical obstacle. Peptidyl-prolyl isomerase Pin1 is prominently ove...

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Bibliographic Details
Main Authors: Songyin Huang, Yang Chen, Zhi-Mei Liang, Na-Na Li, Yujie Liu, Yinghua Zhu, Dingzhun Liao, Xiao Zhen Zhou, Kun Ping Lu, Yandan Yao, Man-Li Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ATRA
Pin1
breast cancer
tamoxifen
ERα
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00322/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00322/full

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