A three-marker FISH panel detects more genetic aberrations of AR, PTEN and TMPRSS2/ERG in castration-resistant or metastatic prostate cancers than in primary prostate tumors.

A three-marker FISH panel detects more genetic aberrations of AR, PTEN and TMPRSS2/ERG in castration-resistant or metastatic prostate cancers than in primary prostate tumors.

TMPRSS2/ERG rearrangement, PTEN gene deletion, and androgen receptor (AR) gene amplification have been observed in various stages of human prostate cancer. We hypothesized that using these markers as a combined panel would allow better differentiation between low-risk and high-risk prostate cancer....

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Bibliographic Details
Main Authors: Xiaoyu Qu, Grace Randhawa, Cynthia Friedman, Brenda F Kurland, Lena Glaskova, Ilsa Coleman, Elahe Mostaghel, Celestia S Higano, Christopher Porter, Robert Vessella, Peter S Nelson, Min Fang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3787014?pdf=render

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http://europepmc.org/articles/PMC3787014?pdf=render

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