Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death.

Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death.

Glaucoma, the most frequent optic neuropathy, is a leading cause of blindness worldwide. Death of retinal ganglion cells (RGCs) occurs in all forms of glaucoma and accounts for the loss of vision, however the molecular mechanisms that cause RGC loss remain unclear. The pro-apoptotic molecule, Fas li...

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Bibliographic Details
Main Authors: Meredith S Gregory, Caroline G Hackett, Emma F Abernathy, Karen S Lee, Rebecca R Saff, Andreas M Hohlbaum, Krishna-Sulayman L Moody, Maura W Hobson, Alexander Jones, Paraskevi Kolovou, Saoussen Karray, Andrea Giani, Simon W M John, Dong Feng Chen, Ann Marshak-Rothstein, Bruce R Ksander
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3066205?pdf=render

Internet

http://europepmc.org/articles/PMC3066205?pdf=render

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