MeCP2 represses the activity of topoisomerase IIβ in long neuronal genes

MeCP2 represses the activity of topoisomerase IIβ in long neuronal genes

Summary: A unique signature of neurons is the high expression of the longest genes in the genome. These genes have essential neuronal functions, and disruption of their expression has been implicated in neurological disorders. DNA topoisomerases resolve DNA topological constraints and facilitate neu...

Full description

Bibliographic Details
Main Authors: Sabin A. Nettles, Yoshiho Ikeuchi, Katheryn B. Lefton, Ladan Abbasi, Alyssa Erickson, Chibueze Agwu, Thomas Papouin, Azad Bonni, Harrison W. Gabel
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015504

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723015504

Similar Items