Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment

Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment

Abstract Despite tremendous progress in deciphering breast cancer at the genomic level, the pronounced intra- and intertumoral heterogeneity remains a major obstacle to the advancement of novel and more effective treatment approaches. Frequent treatment failure and the development of treatment resis...

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Bibliographic Details
Main Authors: Nicole Anderle, Felix Schäfer-Ruoff, Annette Staebler, Nicolas Kersten, André Koch, Cansu Önder, Anna-Lena Keller, Simone Liebscher, Andreas Hartkopf, Markus Hahn, Markus Templin, Sara Y. Brucker, Katja Schenke-Layland, Christian Schmees
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Preclinical tumor model
Tumor heterogeneity
Therapy resistance
Therapy sensitivity
Protein profiling
Breast cancer
Online Access:https://doi.org/10.1186/s13046-023-02782-2

Internet

https://doi.org/10.1186/s13046-023-02782-2

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