Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Abstract Background Intrauterine inflammation (IUI) alters epigenetic modifications in offspring, leading to lung injury. However, the epigenetic mechanism underlying IUI-induced lung injury remains uncertain. In the present study, we aim to investigate the effect of IUI on lung development, and to...

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Bibliographic Details
Main Authors: Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding, Zhiwei Liu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Cell & Bioscience
Subjects:
Serpine1
Intrauterine inflammation
Lung injury
Cell senescence
Hypomethylation
Online Access:https://doi.org/10.1186/s13578-022-00901-8

Internet

https://doi.org/10.1186/s13578-022-00901-8

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