Overexpression of <named-content content-type="genus-species">Plasmodium berghei</named-content> ATG8 by Liver Forms Leads to Cumulative Defects in Organelle Dynamics and to Generation of Noninfectious Merozoites

ABSTRACT Plasmodium parasites undergo continuous cellular renovation to adapt to various environments in the vertebrate host and insect vector. In hepatocytes, Plasmodium berghei discards unneeded organelles for replication, such as micronemes involved in invasion. Concomitantly, intrahepatic parasi...

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Bibliographic Details
Main Authors: Christiane Voss, Karen Ehrenman, Godfree Mlambo, Satish Mishra, Kota Arun Kumar, John B. Sacci, Photini Sinnis, Isabelle Coppens
Format: Article
Language:English
Published: American Society for Microbiology 2016-07-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00682-16