Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

<p>Abstract</p> <p>Background</p> <p>The sphingosine 1-phosphate (S1P) receptor modulator FTY720P (Gilenya®) potently reduces relapse rate and lesion activity in the neuroinflammatory disorder multiple sclerosis. Although most of its efficacy has been shown to be relate...

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Bibliographic Details
Main Authors: van Doorn Ruben, Lopes Pinheiro Melissa A, Kooij Gijs, Lakeman Kim, van het Hof Bert, van der Pol Susanne MA, Geerts Dirk, van Horssen Jack, van der Valk Paul, van der Kam Elizabeth, Ronken Eric, Reijerkerk Arie, de Vries Helga E
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Journal of Neuroinflammation
Subjects:
Sphingosine 1-phosphate (S1P) receptor
FTY720P
Blood–brain barrier
Neuroinflammation
Monocyte
Multiple sclerosis
Online Access:http://www.jneuroinflammation.com/content/9/1/133

Internet

http://www.jneuroinflammation.com/content/9/1/133

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