SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling

SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling

T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of activated T cells. While the role of TCR clustering in T cell activation has been extensively investigate...

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Bibliographic Details
Main Authors: Manuela Ecker, Richard Schregle, Natasha Kapoor-Kaushik, Pascal Rossatti, Verena M Betzler, Daryan Kempe, Maté Biro, Nicholas Ariotti, Gregory MI Redpath, Jeremie Rossy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
T cells
CD28
membrane curvature
membrane organisation
signalling
sorting nexin 9
Online Access:https://elifesciences.org/articles/67550

Internet

https://elifesciences.org/articles/67550

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