SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling
T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of activated T cells. While the role of TCR clustering in T cell activation has been extensively investigate...
Main Authors: | Manuela Ecker, Richard Schregle, Natasha Kapoor-Kaushik, Pascal Rossatti, Verena M Betzler, Daryan Kempe, Maté Biro, Nicholas Ariotti, Gregory MI Redpath, Jeremie Rossy |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-01-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/67550 |
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