Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

Despite an unprecedented global research effort on SARS-CoV-2, early replication events remain poorly understood. Given the clinical importance of emergent viral variants with increased transmission, there is an urgent need to understand the early stages of viral replication and transcription. We us...

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Bibliographic Details
Main Authors: Jeffrey Y Lee, Peter AC Wing, Dalia S Gala, Marko Noerenberg, Aino I Järvelin, Joshua Titlow, Xiaodong Zhuang, Natasha Palmalux, Louisa Iselin, Mary Kay Thompson, Richard M Parton, Maria Prange-Barczynska, Alan Wainman, Francisco J Salguero, Tammie Bishop, Daniel Agranoff, William James, Alfredo Castello, Jane A McKeating, Ilan Davis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
COVID-19
SARS-CoV-2
variant of concern
B.1.1.7
single-molecule fluorescence in situ hybridisation
early replication
Online Access:https://elifesciences.org/articles/74153

Internet

https://elifesciences.org/articles/74153

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