Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage

Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage

Abstract Signal-Peptide Peptidase Like-3 (SPPL3) is an intramembrane cleaving aspartyl protease that causes secretion of extracellular domains from type-II transmembrane proteins. Numerous Golgi-localized glycosidases and glucosyltransferases have been identified as physiological SPPL3 substrates. B...

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Main Authors: Alkmini A. Papadopoulou, Walter Stelzer, Mara Silber, Christine Schlosser, Charlotte Spitz, Martina Haug-Kröper, Tobias Straub, Stephan A. Müller, Stefan F. Lichtenthaler, Claudia Muhle-Goll, Dieter Langosch, Regina Fluhrer
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24772-8

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https://doi.org/10.1038/s41598-022-24772-8

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