Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

Summary: Interaction with microenvironmental factors is crucial for the regulation of hematopoietic stem cell (HSC) function. Stroma derived factor (SDF)-1α supports HSCs in the quiescent state and is central to the homing of transplanted HSCs. Here, we show that integrin signaling regulates Sdf-1α...

Full description

Bibliographic Details
Main Authors: Irene Mariam Roy, P.V. Anu, Samantha Zaunz, Srinu Reddi, Aravind M. Giri, Rithika Saroj Sankar, Sarah Schouteden, Joerg Huelsken, Catherine M. Verfaillie, Satish Khurana
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Biological sciences
cell biology
stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222014432

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222014432

Similar Items