Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB Inhibitor <i>N</i><sub>4</sub>-Methyltalpinine

Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB Inhibitor <i>N</i><sub>4</sub>-Methyltalpinine

The unification of the general synthetic strategy regarding the important and emerging group of C-19 methyl-substituted sarpagine/macroline alkaloids has culminated in the completion of the total synthesis of several bioactive alkaloids. Key transformations include an ACE-Cl mediated late-stage N(4)...

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Bibliographic Details
Main Authors: Md Toufiqur Rahman, Veera Venkata Naga Phani Babu Tiruveedhula, Michael Rajesh Stephen, Sundari K. Rallapalli, Kamal P. Pandey, James M. Cook
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
sarpagine alkaloids
macroline alkaloids
macrocarpine F
macrocarpine G
talpinine
<i>O</i>-acetyltalpinine
Online Access:https://www.mdpi.com/1420-3049/27/5/1738

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https://www.mdpi.com/1420-3049/27/5/1738

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