Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice

Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice

Objective: Pharmacological strategies that engage multiple mechanisms-of-action have demonstrated synergistic benefits for metabolic disease in preclinical models. One approach, concurrent activation of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and glucagon...

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Bibliographic Details
Main Authors: Patrick J. Knerr, Stephanie A. Mowery, Jonathan D. Douros, Bhavesh Premdjee, Karina Rahr Hjøllund, Yantao He, Ann Maria Kruse Hansen, Anette K. Olsen, Diego Perez-Tilve, Richard D. DiMarchi, Brian Finan
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Metabolism
Subjects:
Obesity
Pharmacology
Triagonist
Glucagon
GLP-1
GIP
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001028

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http://www.sciencedirect.com/science/article/pii/S2212877822001028

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