The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c

The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c

Mycobacterium tuberculosis bifunctional enzyme GlmU is a novel target for anti-TB drugs and is involved in glycosyl donor UDP-N-acetylglucosamine biosynthesis. Here, we found that TPSA (2-[5-(2-{[4-(2-thienyl)-2-pyrimidinyl]sulfanyl}acetyl)-2-thienyl]acetic acid) was a novel inhibitor for GlmU acety...

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Bibliographic Details
Main Authors: Changming Chen, Xiuyan Han, Qiulong Yan, Chao Wang, Liqiu Jia, Ayaz Taj, Lizhe Zhao, Yufang Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacteria tuberculosis
UDP-GlcNAc
GlmU acetyltransferase
inhibitor
methyltransferases
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00251/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00251/full

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