Modeling of senescence-related chemoresistance in ovarian cancer using data analysis and patient-derived organoids

Modeling of senescence-related chemoresistance in ovarian cancer using data analysis and patient-derived organoids

BackgroundOvarian cancer (OC) is a malignant tumor associated with poor prognosis owing to its susceptibility to chemoresistance. Cellular senescence, an irreversible biological state, is intricately linked to chemoresistance in cancer treatment. We developed a senescence-related gene signature for...

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Bibliographic Details
Main Authors: Xintong Cai, Yanhong Li, Jianfeng Zheng, Li Liu, Zicong Jiao, Jie Lin, Shan Jiang, Xuefen Lin, Yang Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Oncology
Subjects:
cell senescence
chemoresistance
ovarian cancer
organoid
TCGA
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1291559/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1291559/full

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