Simultaneous separation of naproxen and 6-O-desmethylnaproxen metabolite in saliva samples by liquid chromatography-tandem mass spectrometry: Pharmacokinetic study of naproxen alone and associated with esomeprazol—Results

Simultaneous separation of naproxen and 6-O-desmethylnaproxen metabolite in saliva samples by liquid chromatography-tandem mass spectrometry: Pharmacokinetic study of naproxen alone and associated with esomeprazol—Results

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After performing liquid-liquid extraction with ethyl acetate and HCl, samples from 12 volunteers who performed sequential collections after taking a tablet of naproxen alone (n = 6) or associated with esomeprazole (n = 6) were analyzed in a triple quadrupole mass spectrometer 8040 LC MS/MS Shimadzu....

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Bibliographic Details
Main Authors: Gabriela Moraes Oliveira, Thiago José Dionísio, Nelson Leonel Del Hierro Polanco, Viviane Silva Siqueira-Sandrin, Flavio Augusto Cardoso Faria, Carlos Ferreira Santos, Adriana Maria Calvo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714831/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714831/?tool=EBI

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