Decrease in Brain Distribution of Fluvoxamine in Experimental Hyperlipidemic Rats

ABSTRACT: Purpose. Many clinical reports and trials have suggested that fluvoxamine (FLV) reduces plasma lipoprotein levels. However, few studies have reported the effect of plasma lipoproteins on FLV pharmacokinetics. The aim of the present study was to investigate the affinities of FLV to plasma l...

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Bibliographic Details
Main Authors: Keizo Fukushima, Shinji Kobuchi, Masakazu Shibata, Kanji Takada, Nobuyuki Sugioka
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-11-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/11029