Positive selection-driven fixation of a hominin-specific amino acid mutation related to dephosphorylation in IRF9

Positive selection-driven fixation of a hominin-specific amino acid mutation related to dephosphorylation in IRF9

Abstract The arms race between humans and pathogens drives the evolution of the human genome. It is thus expected that genes from the interferon-regulatory factors family (IRFs), a critical family for anti-viral immune response, should be undergoing episodes of positive selection. Herein, we tested...

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Bibliographic Details
Main Authors: Jianhai Chen, Xuefei He, Ivan Jakovlić
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Ecology and Evolution
Subjects:
Protein phosphorylation
Positive selection
Purifying selection
Molecular adaptation
IRF9
Online Access:https://doi.org/10.1186/s12862-022-02088-5

Internet

https://doi.org/10.1186/s12862-022-02088-5

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