Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive Function

Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive Function

Synaptopathies contributing to neurodevelopmental disorders are linked to mutations in synaptic organizing molecules, including postsynaptic neuroligins, presynaptic neurexins, and MDGAs, which regulate their interaction. The role of MDGA1 in suppressing inhibitory versus excitatory synapses is cont...

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Bibliographic Details
Main Authors: Steven A. Connor, Ina Ammendrup-Johnsen, Yasushi Kishimoto, Parisa Karimi Tari, Vedrana Cvetkovska, Takashi Harada, Daiki Ojima, Tohru Yamamoto, Yu Tian Wang, Ann Marie Craig
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
Neuroligin
neurexin
synapse development
inhibitory synapse
hippocampus
synaptic plasticity
neurodevelopmental disorders
E/I ratio
memory
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471731793X

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http://www.sciencedirect.com/science/article/pii/S221112471731793X

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